NEJM (New England Journal of Medicine) Submission Requirements
Validate your manuscript against the New England Journal of Medicine's submission requirements before submission to this general-medicine flagship.
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What NEJM requires
The New England Journal of Medicine (NEJM) is one of the most selective general-medicine journals, publishing major clinical research for a broad medical readership. NEJM Original Articles use a structured abstract and expect prospective trial registration in a public registry, a data-sharing statement, completed author-disclosure forms, and reporting that follows the relevant guideline (CONSORT for randomised trials). Exact length, figure, and reference limits are specified in NEJM's own author instructions and should be confirmed there. CheckMyManuscript flags the presence and structure of these elements before submission.
NEJM requirements, and what CMM checks
These are structural expectations common to NEJM submissions. Exact numeric limits live in NEJM's author instructions; verify them there.
Structured abstract
✓ CMM checks thisA structured abstract for original research (e.g. Background, Methods, Results, Conclusions).
Flag: an unstructured abstract for an Original Article.
Source: nejm.org · verified Jun 16, 2026
Trial registration
✓ CMM checks thisProspective registration of clinical trials in a public registry, with the registration number reported.
Flag: a randomised trial with no registration number.
Source: nejm.org · verified Jun 16, 2026
Data-sharing statement
✓ CMM checks thisA data-sharing statement, as expected for clinical trials.
Source: nejm.org · verified Jun 16, 2026
Author disclosures
✓ CMM checks thisCompleted conflict-of-interest / disclosure forms for all authors.
Source: nejm.org · verified Jun 16, 2026
Reporting guideline
✓ CMM checks thisCONSORT (trials), PRISMA (reviews), or STROBE (observational), with the completed checklist.
Source: equator-network.org · verified Jun 16, 2026
Length & format limits
✓ CMM checks thisWord, figure, and reference limits as specified in NEJM author instructions, verify directly (crawler-restricted).
CMM flags an over-length manuscript once you set the journal's limit.
Source: nejm.org · verified Jun 16, 2026
Clinical importance & novelty
Editorial, not auto-checkableWhether the findings are important enough for NEJM's broad readership.
Editorial judgement, not auto-checkable.
Source: nejm.org · verified Jun 16, 2026
NEJM restricts automated access to its author center, so exact word, figure, and reference limits are NOT stated here, verify them directly in NEJM's author instructions before submitting. The items below are structural expectations common to NEJM submissions. CheckMyManuscript checks presence and structure, not methodological quality. Last checked 16 June 2026.
The New England Journal of Medicine is among the most competitive general-medicine journals. It expects a structured abstract, prospective trial registration, a data-sharing statement, completed disclosures, and reporting-guideline compliance. Because NEJM restricts automated access to its author center, confirm exact word, figure, and reference limits directly in its author instructions. CheckMyManuscript screens your manuscript for the presence and structure of these elements before submission.
What CheckMyManuscript checks, and what it does not
CheckMyManuscript flags structural signals: an unstructured abstract, a missing trial registration number, no data-sharing statement, or incomplete disclosures. It does not judge whether the findings are important enough for NEJM or whether the methods were sound. Those are editorial and methodological judgements. Use the checker as a pre-submission completeness screen, not a compliance certificate.
Also see: The Lancet checker | JAMA checker | CONSORT checklist checker
What gets returned before review at NEJM
Common structural reasons general-medicine manuscripts are returned at the editorial screen, each maps to a signal CMM can flag.
1.
Unstructured abstract
An Original Article submitted with a narrative abstract instead of a structured one.
CMM checks for: Structured abstract
2.
Trial registration missing
A randomised trial with no prospective registration number.
CMM checks for: Trial registration
3.
No data-sharing statement
A clinical trial submitted without a data-sharing statement.
CMM checks for: Data-sharing statement
4.
Incomplete disclosures
Conflict-of-interest forms missing for one or more authors.
CMM checks for: Author disclosures
NEJM checks
Structured abstract
Flags an unstructured abstract for original research.
Trial registration
Flags a missing trial registration number.
Data sharing
Flags an absent data-sharing statement for trials.
Disclosures
Flags incomplete author conflict-of-interest disclosures.
Reporting guideline
Flags a missing CONSORT/PRISMA/STROBE checklist.
Checks relevant to this topic
Part of our 80+ automated checks
Structured abstract
Structured abstract present for original research.
Trial registration
Trial registration number reported.
Data-sharing statement
Data-sharing statement present.
Author disclosures
Disclosure forms for all authors.
Reporting guideline
Design-appropriate checklist present.
The practical edge your peers already use
Across disciplines and career stages, researchers reduce bottlenecks and submit with confidence: clearer drafts, easier guideline compliance, and less back and forth with co‑authors and reviewers.
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Professor in Mechanical Engineering, ÉTS Montréal
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Master's Student in Speech Therapy
I write research in both Portuguese and English, and it adapts perfectly to either language. It provided precise feedback in Portuguese, helping me maintain academic tone and consistency across my drafts.
Afonso
PhD Candidate, UFPE
It gave excellent advice on how to rephrase and present ideas more clearly and concisely. The suggestions helped me refine my arguments and make my research more impactful.
Félix
Postdoc Researcher, Max Planck Institute for Evolutionary Biology
A round of suggestions helped to generally refine the text of my paper and, moreover, to present some of its key points in a more focused form.
Oleg
Professor, Pirogov Russian National Research Medical University
I use it to review my students' papers. It instantly highlights typos, missing references, and unclear sections, helping me focus my feedback on the quality of the research instead of surface errors.
Ilyass
Professor in Mechanical Engineering, ÉTS Montréal
I relied on it throughout my thesis to strengthen my writing. It suggested clearer phrasing, improved flow between sections, and ensured my references were complete before the final deadline.
Manon
Master's Student in Speech Therapy
I write research in both Portuguese and English, and it adapts perfectly to either language. It provided precise feedback in Portuguese, helping me maintain academic tone and consistency across my drafts.
Afonso
PhD Candidate, UFPE
It gave excellent advice on how to rephrase and present ideas more clearly and concisely. The suggestions helped me refine my arguments and make my research more impactful.
Félix
Postdoc Researcher, Max Planck Institute for Evolutionary Biology
A round of suggestions helped to generally refine the text of my paper and, moreover, to present some of its key points in a more focused form.
Oleg
Professor, Pirogov Russian National Research Medical University
Frequently asked questions
NEJM Original Articles use a structured abstract. The exact subheadings and word limit are specified in NEJM's author instructions; confirm them there, because NEJM restricts automated access and limits can change.
Yes. NEJM, in line with ICMJE-style expectations, requires prospective registration of clinical trials in a public registry and the registration number to be reported. A trial without registration is commonly returned.
No. CheckMyManuscript checks the presence and structure of required elements such as the structured abstract, trial registration, and disclosures. It does not judge clinical importance or methodological quality, and it does not replace peer review.