SPIRIT 2025 Checklist Checker
Check your clinical trial protocol against the SPIRIT 2025 reporting checklist before submission or registration.
Check my manuscript, it's freeNo account required · Results in <2 minutes · PDF, Word & LaTeX
What the SPIRIT 2025 checklist requires
SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) is the EQUATOR-endorsed reporting guideline for clinical trial protocols. SPIRIT 2025, which replaces SPIRIT 2013 and was developed alongside CONSORT 2025, covers administrative information, introduction, methods (participants, interventions, outcomes, assignment, data collection and management, statistics, monitoring), ethics and dissemination, and appendices, plus a schedule of enrolment, interventions, and assessments. CheckMyManuscript flags missing or structurally incomplete SPIRIT items, such as no registration, an absent schedule figure, or missing ethics and consent sections, so you can fix them before submission. It checks presence and structure, not scientific adequacy.
SPIRIT 2025 items, and what CMM checks
Each item below maps to SPIRIT 2025. CMM flags presence and structural signals; scientific and methodological adequacy is editorial and needs human review.
Administrative information
✓ CMM checks thisDescriptive title, trial registration and dataset, protocol version, funding, and roles/responsibilities.
Flag: no trial registration identifier in the protocol.
Source: consort-spirit.org · verified Jun 16, 2026
Eligibility, interventions & outcomes
✓ CMM checks thisEligibility criteria, the interventions for each group, and clearly defined primary and secondary outcomes.
Source: consort-spirit.org · verified Jun 16, 2026
Schedule of enrolment, interventions & assessments
✓ CMM checks thisThe SPIRIT figure showing the timing of enrolment, interventions, and assessments.
Flag: no SPIRIT schedule figure.
Source: consort-spirit.org · verified Jun 16, 2026
Sample size, allocation & blinding
✓ CMM checks thisHow sample size was determined, sequence generation, allocation concealment, and blinding.
Source: consort-spirit.org · verified Jun 16, 2026
Monitoring, harms & auditing
✓ CMM checks thisData monitoring arrangements, harms collection, and any auditing of trial conduct.
Source: consort-spirit.org · verified Jun 16, 2026
Ethics & dissemination
✓ CMM checks thisEthics approval, informed-consent process, confidentiality, declaration of interests, data access, and dissemination policy.
Flag: missing informed-consent or ethics-approval section.
Source: consort-spirit.org · verified Jun 16, 2026
Scientific justification adequacy
Editorial, not auto-checkableWhether the design, sample size, and analysis plan are scientifically sound for the question.
Editorial judgement, outside the scope of an automated checker.
Source: equator-network.org · verified Jun 16, 2026
This page reflects SPIRIT 2025, the current version, which replaces SPIRIT 2013 and was developed alongside CONSORT 2025. CheckMyManuscript checks for the presence, structure, and likely-completeness signals of each protocol item; it does not assess scientific or methodological adequacy and does not replace peer review. Verify the live checklist before submitting, last checked 16 June 2026.
SPIRIT 2025 is the reporting standard for clinical trial protocols, replacing SPIRIT 2013. Journals, funders, and ethics committees expect SPIRIT-compliant protocols, and SPIRIT 2025 was designed alongside CONSORT 2025 so your protocol and eventual trial report stay aligned. CheckMyManuscript screens your protocol for the presence and structure of each SPIRIT item so preventable gaps are caught before submission.
What CheckMyManuscript checks, and what it does not
CheckMyManuscript flags structural signals: a missing registration identifier, an absent schedule figure, undefined outcomes, or missing ethics and consent sections. It does not judge whether the trial design, sample size, or analysis plan are scientifically appropriate. Those are methodological and ethical judgements for peer and committee review. Use the checker as a pre-submission completeness screen, not a compliance certificate.
Also see: CONSORT checklist checker | PRISMA checklist checker | The Lancet submission checker
SPIRIT-specific checks
Trial registration
Flags a missing trial registration identifier in the protocol.
Schedule figure
Flags an absent SPIRIT schedule of enrolment, interventions, and assessments.
Outcomes defined
Flags if primary/secondary outcomes are not clearly defined.
Allocation & blinding
Flags missing sequence-generation, concealment, or blinding sections.
Monitoring & harms
Flags absent data-monitoring or harms sections.
Ethics & consent
Flags missing ethics-approval or informed-consent sections.
Checks relevant to this topic
Part of our 80+ automated checks
Registration in protocol
Trial registration identifier present.
Schedule figure
SPIRIT schedule figure included.
Outcomes defined
Primary/secondary outcomes specified.
Monitoring section
Data-monitoring arrangements reported.
Ethics & consent
Ethics approval and consent reported.
The practical edge your peers already use
Across disciplines and career stages, researchers reduce bottlenecks and submit with confidence: clearer drafts, easier guideline compliance, and less back and forth with co‑authors and reviewers.
I use it to review my students' papers. It instantly highlights typos, missing references, and unclear sections, helping me focus my feedback on the quality of the research instead of surface errors.
Ilyass
Professor in Mechanical Engineering, ÉTS Montréal
I relied on it throughout my thesis to strengthen my writing. It suggested clearer phrasing, improved flow between sections, and ensured my references were complete before the final deadline.
Manon
Master's Student in Speech Therapy
I write research in both Portuguese and English, and it adapts perfectly to either language. It provided precise feedback in Portuguese, helping me maintain academic tone and consistency across my drafts.
Afonso
PhD Candidate, UFPE
It gave excellent advice on how to rephrase and present ideas more clearly and concisely. The suggestions helped me refine my arguments and make my research more impactful.
Félix
Postdoc Researcher, Max Planck Institute for Evolutionary Biology
A round of suggestions helped to generally refine the text of my paper and, moreover, to present some of its key points in a more focused form.
Oleg
Professor, Pirogov Russian National Research Medical University
I use it to review my students' papers. It instantly highlights typos, missing references, and unclear sections, helping me focus my feedback on the quality of the research instead of surface errors.
Ilyass
Professor in Mechanical Engineering, ÉTS Montréal
I relied on it throughout my thesis to strengthen my writing. It suggested clearer phrasing, improved flow between sections, and ensured my references were complete before the final deadline.
Manon
Master's Student in Speech Therapy
I write research in both Portuguese and English, and it adapts perfectly to either language. It provided precise feedback in Portuguese, helping me maintain academic tone and consistency across my drafts.
Afonso
PhD Candidate, UFPE
It gave excellent advice on how to rephrase and present ideas more clearly and concisely. The suggestions helped me refine my arguments and make my research more impactful.
Félix
Postdoc Researcher, Max Planck Institute for Evolutionary Biology
A round of suggestions helped to generally refine the text of my paper and, moreover, to present some of its key points in a more focused form.
Oleg
Professor, Pirogov Russian National Research Medical University
Frequently asked questions
Use SPIRIT 2025, the current version that replaces SPIRIT 2013. It was developed together with CONSORT 2025, so a protocol prepared with SPIRIT 2025 aligns with the trial report you will later write to CONSORT 2025. Confirm the requirements of your target journal or registry.
No. CheckMyManuscript checks the presence, structure, and likely-completeness signals of SPIRIT items, for example, whether registration, a schedule figure, and ethics/consent sections exist. It does not assess whether the trial design or sample-size calculation is scientifically sound, and it does not replace peer or ethics review.
SPIRIT recommends a figure showing the schedule of enrolment, interventions, and assessments across the trial timeline. It lets reviewers and ethics committees see when each procedure occurs. A protocol without this figure is commonly queried.